a:5:{s:8:"template";s:8138:"<!DOCTYPE html>
<html lang="en-US">

<head>
<meta charset="utf-8"/>
<meta content="width=device-width" name="viewport"/>
<title>{{ keyword }}</title>
<link href="http://gmpg.org/xfn/11" rel="profile"/>


<link href="http://fonts.googleapis.com/css?family=Open+Sans:400italic,700italic,400,700&amp;subset=latin,latin-ext" id="twentytwelve-fonts-css" media="all" rel="stylesheet" type="text/css"/>
<style id="twentytwelve-style-css" media="all" rel="stylesheet" type="text/css">/*



/* =Reset
-------------------------------------------------------------- */

html, body, div, h1, h2, h3, a, ul, li, footer, header, hgroup, nav {
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	padding: 0;
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	font-size: 100%;
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body {
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ul {
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h1,
h2,
h3 {
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html {
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	font-size: 100%;
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a:focus {
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footer,
header,
hgroup,
nav {
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}

/* Clearing floats */
.wrapper:after {
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}
.wrapper:before,
.wrapper:after {
	display: table;
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.menu-toggle {
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.menu-toggle {
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.menu-toggle:hover {
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/* Body, links, basics */
html {
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body {
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}
body.custom-font-enabled {
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a {
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a:hover {
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}

/* Assistive text */
.assistive-text {
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.main-navigation .assistive-text:hover,
.main-navigation .assistive-text:active,
.main-navigation .assistive-text:focus {
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	border-radius: 3px;
	clip: auto !important;
	color: #000;
	display: block;
	font-size: 12px;
	padding: 12px;
	position: absolute;
	top: 5px;
	left: 5px;
	z-index: 100000; /* Above WP toolbar */
}

/* Page structure */
.site {
	padding: 0 24px;
	padding: 0 1.714285714rem;
	background-color: #fff;
}

/* Header */
.site-header {
	padding: 24px 0;
	padding: 1.714285714rem 0;
}
.site-header h1,
.site-header h2 {
	text-align: center;
}
.site-header h1 a {
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	display: inline-block;
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}
.site-header h1 a:hover {
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.site-header h1 {
	font-size: 24px;
	font-size: 1.714285714rem;
	line-height: 1.285714286;
	margin-bottom: 14px;
	margin-bottom: 1rem;
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.site-header h2 {
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	font-size: 0.928571429rem;
	line-height: 1.846153846;
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/* Navigation Menu */
.main-navigation {
	margin-top: 24px;
	margin-top: 1.714285714rem;
	text-align: center;
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.main-navigation li {
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	margin-top: 1.714285714rem;
	font-size: 12px;
	font-size: 0.857142857rem;
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.main-navigation a {
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.main-navigation a:hover {
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}
.main-navigation div.nav-menu > ul {
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}
.menu-toggle {
	display: inline-block;
}

/* Banner */

/* Sidebar */

/* Footer */
footer[role="contentinfo"] {
	border-top: 1px solid #ededed;
	clear: both;
	font-size: 12px;
	font-size: 0.857142857rem;
	line-height: 2;
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	max-width: 68.571428571rem;
	margin-top: 24px;
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	padding: 24px 0;
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}
footer[role="contentinfo"] a {
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footer[role="contentinfo"] a:hover {
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}


/* Minimum width of 600 pixels. */
@media screen and (min-width: 600px) {
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		max-width: 960px;
		max-width: 68.571428571rem;
		overflow: hidden;
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	.site-header h1,
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		line-height: 1.846153846;
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	.main-navigation div.nav-menu > ul {
		border-bottom: 1px solid #ededed;
		border-top: 1px solid #ededed;
		display: inline-block !important;
		text-align: left;
		width: 100%;
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	.main-navigation ul {
		margin: 0;
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	.main-navigation li a,
	.main-navigation li {
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	.main-navigation li a {
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		color: #6a6a6a;
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	.main-navigation li a:hover {
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	.main-navigation li {
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		margin: 0 2.857142857rem 0 0;
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	.menu-toggle {
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}

/* Minimum width of 960 pixels. */
@media screen and (min-width: 960px) {
	body {
		background-color: #e6e6e6;
	}
	body .site {
		padding: 0 40px;
		padding: 0 2.857142857rem;
		margin-top: 48px;
		margin-top: 3.428571429rem;
		margin-bottom: 48px;
		margin-bottom: 3.428571429rem;
		box-shadow: 0 2px 6px rgba(100, 100, 100, 0.3);
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}


/* =Print
----------------------------------------------- */

@media print {
	body {
		background: none !important;
		color: #000;
		font-size: 10pt;
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	a {
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	.site {
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	.site-header {
		margin-bottom: 72px;
		margin-bottom: 5.142857143rem;
		text-align: left;
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	.site-header h1 {
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		text-align: left;
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	.site-header h2 {
		color: #000;
		font-size: 10pt;
		text-align: left;
	}
	.site-header h1 a {
		color: #000;
	}
	#colophon,
	.main-navigation {
		display: none;
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	.wrapper {
		border-top: none;
		box-shadow: none;
	}
}
</style>


<style type="text/css">.recentcomments a{display:inline !important;padding:0 !important;margin:0 !important;}</style>
</head>
<body class="custom-font-enabled single-author">
<div class="hfeed site" id="page">
<header class="site-header" id="masthead" role="banner">
<hgroup>
<h1 class="site-title"><a href="#" rel="home" title="{{ keyword }}">{{ keyword }}</a></h1>
<h2 class="site-description">Just another WordPress site</h2>
</hgroup>
<nav class="main-navigation" id="site-navigation" role="navigation">
<h3 class="menu-toggle">Menu</h3>
<a class="assistive-text" href="#" title="Skip to content">Skip to content</a>
<div class="nav-menu"><ul><li><a href="#" title="Home">Home</a></li><li class="page_item page-item-2"><a href="#">Sample Page</a></li></ul></div>
</nav>
</header>
<div class="wrapper" id="main">
{{ text }}
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<footer id="colophon" role="contentinfo">
{{ links }}
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</body>
</html>";s:4:"text";s:5728:"Looking for online definition of TP53 or what TP53 stands for? HMTEV168 R273 T125 E56 Y234 C275 R335 R337 V173 K132 C135 ERCSD180del P27 R213 V73 E339 TP53 mutant positions in adrenocortical carcinoma (N=90) Evidence-based recommendations on ibrutinib (Imbruvica) for treating chronic lymphocytic leukaemia in adults BioMed Research International is a peer-reviewed, Open This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. Learn More about Genes. The explanation for these different results could be linked to the fact that the studies were performed on different tumor types and with different therapy regimens. The Optical Superstore offers a wide range of womens glasses and frames. BioGPS is a free extensible and customizable gene annotation portal, a complete resource for learning about gene and protein function. Gene target information for TP53 - tumor protein p53 (human). The TP53 gene provides instructions for making a protein called tumor protein p53 (or p53). TP53 is listed in the World's largest and most authoritative dictionary database of abbreviations and acronyms TP53 mutation is reported to be a factor for good prognosis in some studies, while in others it is a factor for poor prognosis. 6 TP53 Mutations in Acute Myeloid Leukemia 125 6.3 Detection of Alterations of the TP53 Gene TP53 mutation detection can be facilitated by previous screening for mutated cases, In humans, the TP53 gene is located on the short arm of chromosome 17 (17p13.1). What is a gene? TP53 is frequently mutated or inactivated in about 60% of cancers. However, no effective p53-based therapy has been successfully translated into clinical cancer treatment owing to the complexity of ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. IARC TP53 Database: knowledgebase and statistical tools for the analysis of TP53 gene mutations in human cancers n engl j med 373;12 nejm.orgSeptember 17, 2015 1137 Acute Myeloid Leukemia with BCR-ABL1 gene fusion, the need for includ-ing the use of tyrosine kinase inhibitor therapy Tumor protein p53, also known as p53, cellular tumor antigen p53 (UniProt name), phosphoprotein p53, tumor suppressor p53, antigen NY TP53 Gene, Drug Resistance, Tissue Distribution, Mutation Distribution, Variants, TP53 Genome Browser, TP53 References ARUP Laboratories is a national reference laboratory and a worldwide leader in innovative laboratory research and development. View all genes; View TP53 gene homepage; View graphs about the TP53 gene database; View all transcripts; View all transcripts of gene TP53; View all genomic variants A tremendous effort has been made to restore p53 activity in cancer therapies. p53 Structure and Function - Cell Cycle Regualtion & Apoptosis Bio-Resource. My Cancer Genome is managed by the Vanderbilt-Ingram Cancer Center Copyright  2010 - 2017 MY CANCER GENOME Mutations in TP53, CTNNB1 and PIK3CA genes in hepatocellular carcinoma associated with hepatitis B and hepatitis C virus infections What does it mean to have a TP53 gene mutation, and a diagnosis of Li-Fraumeni Syndrome (LFS)? Varleyn Paterson Institute for Cancer Research, Christie NHS Trust, Manchester, UK The gene spans 20 kb, with a non-coding exon 1 How do genes direct the production of proteins? Resale Mobile Homes (Caravans) Spain for sale and Re-sale Park Homes (Static Caravans) in Spain for sale on Residential Parks. MethodsWe enrolled 84 adult patients with AML or MDS in a single-institution trial of decitabine to identify somatic mutations and their relationships to clinical I IA4 Metastasis Suppressor KAI1/CD82 IAP Definition Inhibitor of Apoposis Family IARC Definition International Agency for Research on Cancer. Complete information for TP53 gene (Protein Coding), Tumor Protein P53, including: function, proteins, disorders, pathways, orthologs, and expression. TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use Magali Olivier 1, Monica Hollstein2, and Pierre Hainaut 1Group of Molecular Carcinogenesis, International Agency for Research on Cancer, 150 Cours How can gene mutations affect health and development? p53 REVIEW ARTICLE Germline TP53Mutations and Li-Fraumeni Syndrome J.M. TP53 is found in increased amounts in a wide variety of transformed cells. Screening for germline BRCA1, BRCA2, TP53 and CHEK2 mutations in families at-risk for hereditary breast cancer identified in a population-based study from Southern Brazil qBiomarker Somatic Mutation PCR Array: Human TP53 Gene: The Human TP53 Gene qBiomarker Somatic Mutation PCR Array allows the detection of Cell line Primary tumor Origin of cells Estrogen receptors Progesterone receptors ERBB2 amplification Mutated TP53 Tumorigenic in mice Reference External links Tissue samples were retrieved from the files of the Department of Oral Pathology at the School Loading... ... hence it is also known as TP53 or tumor protein. TP53 Mutation Analysis Overview Mutations in TP53 (Tumor Protein) are found in an estimated 10% of Chronic Lymphocytic Leukemia (CLL) patients at diagnosis.  Gene. What is DNA? BackgroundThe molecular determinants of clinical responses to decitabine therapy in patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) are unclear. 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