a:5:{s:8:"template";s:8138:"<!DOCTYPE html>
<html lang="en-US">

<head>
<meta charset="utf-8"/>
<meta content="width=device-width" name="viewport"/>
<title>{{ keyword }}</title>
<link href="http://gmpg.org/xfn/11" rel="profile"/>


<link href="http://fonts.googleapis.com/css?family=Open+Sans:400italic,700italic,400,700&amp;subset=latin,latin-ext" id="twentytwelve-fonts-css" media="all" rel="stylesheet" type="text/css"/>
<style id="twentytwelve-style-css" media="all" rel="stylesheet" type="text/css">/*



/* =Reset
-------------------------------------------------------------- */

html, body, div, h1, h2, h3, a, ul, li, footer, header, hgroup, nav {
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	padding: 0;
	border: 0;
	font-size: 100%;
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body {
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ul {
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h1,
h2,
h3 {
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html {
	overflow-y: scroll;
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a:focus {
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footer,
header,
hgroup,
nav {
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}

/* Clearing floats */
.wrapper:after {
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}
.wrapper:before,
.wrapper:after {
	display: table;
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.menu-toggle {
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	box-shadow: 0 1px 2px rgba(64, 64, 64, 0.1);
}
.menu-toggle {
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}
.menu-toggle:hover {
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/* Body, links, basics */
html {
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}
body {
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	font-size: 1rem;
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}
body.custom-font-enabled {
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a {
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a:hover {
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}

/* Assistive text */
.assistive-text {
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.main-navigation .assistive-text:hover,
.main-navigation .assistive-text:active,
.main-navigation .assistive-text:focus {
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	border-radius: 3px;
	clip: auto !important;
	color: #000;
	display: block;
	font-size: 12px;
	padding: 12px;
	position: absolute;
	top: 5px;
	left: 5px;
	z-index: 100000; /* Above WP toolbar */
}

/* Page structure */
.site {
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	padding: 0 1.714285714rem;
	background-color: #fff;
}

/* Header */
.site-header {
	padding: 24px 0;
	padding: 1.714285714rem 0;
}
.site-header h1,
.site-header h2 {
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}
.site-header h1 a {
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.site-header h1 a:hover {
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.site-header h1 {
	font-size: 24px;
	font-size: 1.714285714rem;
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.site-header h2 {
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/* Navigation Menu */
.main-navigation {
	margin-top: 24px;
	margin-top: 1.714285714rem;
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.main-navigation li {
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	font-size: 0.857142857rem;
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.main-navigation a {
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.main-navigation a:hover {
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.main-navigation div.nav-menu > ul {
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.menu-toggle {
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/* Banner */

/* Sidebar */

/* Footer */
footer[role="contentinfo"] {
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	clear: both;
	font-size: 12px;
	font-size: 0.857142857rem;
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footer[role="contentinfo"] a {
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footer[role="contentinfo"] a:hover {
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/* Minimum width of 600 pixels. */
@media screen and (min-width: 600px) {
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		max-width: 68.571428571rem;
		overflow: hidden;
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	.site-header h1,
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	.main-navigation div.nav-menu > ul {
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		border-top: 1px solid #ededed;
		display: inline-block !important;
		text-align: left;
		width: 100%;
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	.main-navigation ul {
		margin: 0;
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	.main-navigation li a,
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	.main-navigation li a {
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	.main-navigation li {
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	.menu-toggle {
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}

/* Minimum width of 960 pixels. */
@media screen and (min-width: 960px) {
	body {
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	body .site {
		padding: 0 40px;
		padding: 0 2.857142857rem;
		margin-top: 48px;
		margin-top: 3.428571429rem;
		margin-bottom: 48px;
		margin-bottom: 3.428571429rem;
		box-shadow: 0 2px 6px rgba(100, 100, 100, 0.3);
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}


/* =Print
----------------------------------------------- */

@media print {
	body {
		background: none !important;
		color: #000;
		font-size: 10pt;
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	a {
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	.site {
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	.site-header {
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		margin-bottom: 5.142857143rem;
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	.site-header h1 {
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	.site-header h2 {
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		font-size: 10pt;
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	.site-header h1 a {
		color: #000;
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	#colophon,
	.main-navigation {
		display: none;
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	.wrapper {
		border-top: none;
		box-shadow: none;
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}
</style>


<style type="text/css">.recentcomments a{display:inline !important;padding:0 !important;margin:0 !important;}</style>
</head>
<body class="custom-font-enabled single-author">
<div class="hfeed site" id="page">
<header class="site-header" id="masthead" role="banner">
<hgroup>
<h1 class="site-title"><a href="#" rel="home" title="{{ keyword }}">{{ keyword }}</a></h1>
<h2 class="site-description">Just another WordPress site</h2>
</hgroup>
<nav class="main-navigation" id="site-navigation" role="navigation">
<h3 class="menu-toggle">Menu</h3>
<a class="assistive-text" href="#" title="Skip to content">Skip to content</a>
<div class="nav-menu"><ul><li><a href="#" title="Home">Home</a></li><li class="page_item page-item-2"><a href="#">Sample Page</a></li></ul></div>
</nav>
</header>
<div class="wrapper" id="main">
{{ text }}
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<footer id="colophon" role="contentinfo">
{{ links }}
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</body>
</html>";s:4:"text";s:5467:"Two decades of progress in industrial drug metabolism. This is an essential issue in cancer treatment due to its high toxicity. Role of pharmacokinetics in the discovery and development of indinavir Role of pharmacokinetics in the discovery and development of indinavir Lin, Jiunn H. 1999-10-18 00:00:00 The discovery of indinavir is a successful example in which pharmacokinetic and metabolic information were incorporated into drug design. Compared to other disciplines involved in drug discovery and development, with the possible exception of biotechnology, pharmacokinetics is a relative newcomer. 1 Biologics: Pharmacokinetics and Drug Development Thomayant Prueksaritanont, Ph.D. Merck & Co., Inc. Drug Metabolism and Pharmacokinetics Workshop UNESCO  EOLSS SAMPLE CHAPTERS BIOTECHNOLOGY  Vol .XII  Role of Xenobiotic Metabolism in Drug Discovery and Development - The Role of Pharmacokinetics in Drug Discovery 37 candidates for further development. The purpose of this paper is to review the role of pharmacokinetics and drug metabolism in drug discovery and development from an industrial perspective. This online course is designed to educate scientists and regulatory professionals on drug metabolism and its role in drug discovery and development. Medical Presentation.Drug research encompasses several diverse disciplines united by a common goal, namely the development of novel therapeutic agents. Preclinical drug metabolism and pharmacokinetics ... design faster and more sensitive assay techniques to aid the drug discovery and development. The aim of this current review is to summarize the present status of pharmacokinetics in Drug Discovery. ... Kvalitetsskring 14th Symposium on Pharmacokinetics and Drug Metabolism. ... the process of drug discovery and development.  The review is structured into four sections. The aim of this current review is to summarize the present status of pharmacokinetics in Drug Discovery. Pharmacokinetics, pharmacodynamics and pharmacogenetics play an important role in drug discovery and contribute to treatment success. Pharmacokinetics in Drug Discovery. The pivotal role of drug metabolism and pharmacokinetics in the discovery and development of new medicines Mohammad S Alavijeh & Alan M Palmer* Pharmacokinetics and Pharmacodynamics for Chemists ... of the role of pharmacokinetics in drug development. The intent is to provide a comprehensive, rather than exhaustive, overview of the pertinent literature in the field. The review is structured into four sections. pharmacokinetics in drug discovery and ... have integrated pharmacokinetics and drug metabolism, ... pivotal role in drug discovery and development. We offer an extensive range of preclinical pharmacokinetic studies using multiple animal models for drug discovery and development. Drug Metabolism and Pharmacokinetics (DMPK) is a scientific discipline that has become a core discipline within drug discovery and development. ... play an important role in drug discovery and contribute ... Pharmacokinetics and Metabolism of ... and metabolism in drug discovery and development. Previous article in issue: Pharmacokinetics and its role in small molecule drug discovery research. Pharmacokinetics in Drug Development ... Enzymes involved in drug metabolism are ... in the drug discovery and development process Drug Discovery and Preclinical Development ... Biopharmaceutical Drug Development: Attrition Drug Discovery Pre-Clinical Clinical Trials ... metabolism of drug Successful prediction can be expected to reduce the rate of attrition during drug discovery and development. The main role that DMPK plays in drug discovery is therefore the prediction of drug metabolism and pharmacokinetics in humans. ... of drug metabolism and pharmacokinetics ... discipline in support of drug discovery and development. Medical Presentation.Drug research encompasses several diverse disciplines united by a common goal, namely the development of novel therapeutic agents. Drug metabolism- role in drug ... Drug metabolism- role in drug discovery and development. ... for Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, and ... role in drug discovery and development. ... Pharmacokinetics, Metabolism, ... Preclinical Development: Pharmacokinetics, Metabolism, Pharmaceutics, ... role in drug discovery and development. Drug Metabolism and Pharmacokinetics (DMPK) is a scientific discipline that has become a core discipline within drug discovery and development. This online course is designed to educate scientists and regulatory professionals on drug metabolism and its role in drug discovery and development. This has led to the recognition that DMPK is an essential component of the drug discovery process. It encompasses diverse disciplines united by a common goal, namely the development of novel therapeutic agents for the treatment of diseases. This review described the role of pharmacokinetics and drug metabolism in the discovery and development of indinavir. ... and contribution of drug metabolism and pharmacokinetics to ... at key stages of drug discovery and development. We offer an extensive range of preclinical pharmacokinetic studies using multiple animal models for drug discovery and development. During drug discovery & development, the identification of the DMPK/PD issues of compounds plays an essential role in understanding pharmacological profiles Drug research is an extremely complicated endeavor. 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