a:5:{s:8:"template";s:8138:"<!DOCTYPE html>
<html lang="en-US">

<head>
<meta charset="utf-8"/>
<meta content="width=device-width" name="viewport"/>
<title>{{ keyword }}</title>
<link href="http://gmpg.org/xfn/11" rel="profile"/>


<link href="http://fonts.googleapis.com/css?family=Open+Sans:400italic,700italic,400,700&amp;subset=latin,latin-ext" id="twentytwelve-fonts-css" media="all" rel="stylesheet" type="text/css"/>
<style id="twentytwelve-style-css" media="all" rel="stylesheet" type="text/css">/*



/* =Reset
-------------------------------------------------------------- */

html, body, div, h1, h2, h3, a, ul, li, footer, header, hgroup, nav {
	margin: 0;
	padding: 0;
	border: 0;
	font-size: 100%;
	vertical-align: baseline;
}
body {
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ul {
	list-style: none;
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h1,
h2,
h3 {
	clear: both;
}
html {
	overflow-y: scroll;
	font-size: 100%;
	-webkit-text-size-adjust: 100%;
	-ms-text-size-adjust: 100%;
}
a:focus {
	outline: thin dotted;
}
footer,
header,
hgroup,
nav {
	display: block;
}

/* Clearing floats */
.wrapper:after {
	clear: both;
}
.wrapper:before,
.wrapper:after {
	display: table;
	content: "";
}


.menu-toggle {
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	background-image: -ms-linear-gradient(top, #f4f4f4, #e6e6e6);
	background-image: -webkit-linear-gradient(top, #f4f4f4, #e6e6e6);
	background-image: -o-linear-gradient(top, #f4f4f4, #e6e6e6);
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	box-shadow: 0 1px 2px rgba(64, 64, 64, 0.1);
}
.menu-toggle {
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}
.menu-toggle:hover {
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.menu-toggle:active {
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/* Body, links, basics */
html {
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}
body {
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	font-family: Helvetica, Arial, sans-serif;
	text-rendering: optimizeLegibility;
	color: #444;
}
body.custom-font-enabled {
	font-family: "Open Sans", Helvetica, Arial, sans-serif;
}
a {
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	color: #21759b;
}
a:hover {
	color: #0f3647;
}

/* Assistive text */
.assistive-text {
	position: absolute !important;
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}
.main-navigation .assistive-text:hover,
.main-navigation .assistive-text:active,
.main-navigation .assistive-text:focus {
	background: #fff;
	border: 2px solid #333;
	border-radius: 3px;
	clip: auto !important;
	color: #000;
	display: block;
	font-size: 12px;
	padding: 12px;
	position: absolute;
	top: 5px;
	left: 5px;
	z-index: 100000; /* Above WP toolbar */
}

/* Page structure */
.site {
	padding: 0 24px;
	padding: 0 1.714285714rem;
	background-color: #fff;
}

/* Header */
.site-header {
	padding: 24px 0;
	padding: 1.714285714rem 0;
}
.site-header h1,
.site-header h2 {
	text-align: center;
}
.site-header h1 a {
	color: #515151;
	display: inline-block;
	text-decoration: none;
}
.site-header h1 a:hover {
	color: #21759b;
}
.site-header h1 {
	font-size: 24px;
	font-size: 1.714285714rem;
	line-height: 1.285714286;
	margin-bottom: 14px;
	margin-bottom: 1rem;
}
.site-header h2 {
	font-weight: normal;
	font-size: 13px;
	font-size: 0.928571429rem;
	line-height: 1.846153846;
	color: #757575;
}

/* Navigation Menu */
.main-navigation {
	margin-top: 24px;
	margin-top: 1.714285714rem;
	text-align: center;
}
.main-navigation li {
	margin-top: 24px;
	margin-top: 1.714285714rem;
	font-size: 12px;
	font-size: 0.857142857rem;
	line-height: 1.42857143;
}
.main-navigation a {
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}
.main-navigation a:hover {
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}
.main-navigation div.nav-menu > ul {
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}
.menu-toggle {
	display: inline-block;
}

/* Banner */

/* Sidebar */

/* Footer */
footer[role="contentinfo"] {
	border-top: 1px solid #ededed;
	clear: both;
	font-size: 12px;
	font-size: 0.857142857rem;
	line-height: 2;
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	max-width: 68.571428571rem;
	margin-top: 24px;
	margin-top: 1.714285714rem;
	margin-left: auto;
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	padding: 24px 0;
	padding: 1.714285714rem 0;
}
footer[role="contentinfo"] a {
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footer[role="contentinfo"] a:hover {
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/* Minimum width of 600 pixels. */
@media screen and (min-width: 600px) {
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		max-width: 960px;
		max-width: 68.571428571rem;
		overflow: hidden;
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	.site-header h1,
	.site-header h2 {
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		line-height: 1.846153846;
		margin-bottom: 0;
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	.main-navigation div.nav-menu > ul {
		border-bottom: 1px solid #ededed;
		border-top: 1px solid #ededed;
		display: inline-block !important;
		text-align: left;
		width: 100%;
	}
	.main-navigation ul {
		margin: 0;
		text-indent: 0;
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	.main-navigation li a,
	.main-navigation li {
		display: inline-block;
		text-decoration: none;
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	.main-navigation li a {
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	.main-navigation li a:hover {
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	.main-navigation li {
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		margin: 0 2.857142857rem 0 0;
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	.menu-toggle {
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}

/* Minimum width of 960 pixels. */
@media screen and (min-width: 960px) {
	body {
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	body .site {
		padding: 0 40px;
		padding: 0 2.857142857rem;
		margin-top: 48px;
		margin-top: 3.428571429rem;
		margin-bottom: 48px;
		margin-bottom: 3.428571429rem;
		box-shadow: 0 2px 6px rgba(100, 100, 100, 0.3);
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}


/* =Print
----------------------------------------------- */

@media print {
	body {
		background: none !important;
		color: #000;
		font-size: 10pt;
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	a {
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	.site {
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	.site-header {
		margin-bottom: 72px;
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		text-align: left;
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	.site-header h1 {
		font-size: 21pt;
		line-height: 1;
		text-align: left;
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	.site-header h2 {
		color: #000;
		font-size: 10pt;
		text-align: left;
	}
	.site-header h1 a {
		color: #000;
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	#colophon,
	.main-navigation {
		display: none;
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	.wrapper {
		border-top: none;
		box-shadow: none;
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}
</style>


<style type="text/css">.recentcomments a{display:inline !important;padding:0 !important;margin:0 !important;}</style>
</head>
<body class="custom-font-enabled single-author">
<div class="hfeed site" id="page">
<header class="site-header" id="masthead" role="banner">
<hgroup>
<h1 class="site-title"><a href="#" rel="home" title="{{ keyword }}">{{ keyword }}</a></h1>
<h2 class="site-description">Just another WordPress site</h2>
</hgroup>
<nav class="main-navigation" id="site-navigation" role="navigation">
<h3 class="menu-toggle">Menu</h3>
<a class="assistive-text" href="#" title="Skip to content">Skip to content</a>
<div class="nav-menu"><ul><li><a href="#" title="Home">Home</a></li><li class="page_item page-item-2"><a href="#">Sample Page</a></li></ul></div>
</nav>
</header>
<div class="wrapper" id="main">
{{ text }}
	</div>
<footer id="colophon" role="contentinfo">
{{ links }}
<div class="site-info">
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</footer>
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</body>
</html>";s:4:"text";s:6257:"Cyclin-dependent kinases (Cdks) are serine/threonine kinases and their catalytic activities are modulated by interactions with cyclins and Cdk inhibitors (CKIs). Entry into, progression through, and exit from the G1 phase of the mammalian cell cycle in response to extracellular mitogenic cues are presumed to be governed by cyclin-dependent kinases (Cdks) regulated by the D-type and E-type cyclins. It is activated by binding to cyclin and participates in the regulation of cell cycle. Close cooperation between this trio is necessary for ensuring orderly progression through the cell cycle. The cyclin-dependent kinase 1 (Cdk1), formerly called Cdc2 (or p34 Cdc2), interacts with cyclin B1 to form an active heterodimer. cyclins and cyclin-dependent kinases (CDKs) CDKs are important master regulators of the cell cycle. The protein encoded by this gene is a member of the Ser/Thr protein kinase family. Of the many proteins involved in cell cycle control, cyclin-dependent kinases (CDKs) are among the most important. The cyclin-dependent kinases are a small family of enzymes that. Cyclin-dependent kinases (CDKs) are a family of protein kinases first discovered for their role in regulating the cell cycle. Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs and the cell cycle. shared by all protein kinases. 1. Mammalian cyclin-dependent kinases ... Smad3, thymidine kinase Cell cycle (G1S) CDK3 63 PSTAIRE E1, E2, A1, A2, C E2F/DP Cables1 Cell cycle (G0G1S) The cyclin-dependent kinases (Cdks) are a family of serine/threonine protein kinases whose. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells. CYCLIN DEPENDENT KINASES AND CELL CYCLE CONTROL Nobel Lecture, December 9, 2001 by PAUL M. NURSE Cancer Research UK, PO Box 123, 61 CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues. Cyclin-dependent kinases is a group of serine/threonine kinases. Their role is to phosphorylate proteins on either S or T amino acids and thereby regulate the activity of those proteins. Abstract - Cyclin dependent protein kinases (CDKs) play vital role in gene expression and cell cycle regulation. Cell Cycle Phase Specificity of Putative Cyclin-Dependent ... Cyclin-dependent kinases ... a p34 histone kinase during the cell cycle has been demon-  Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. Cell Cycle Regulation of Cyclin-Dependent Kinases in Tobacco Cultivar Bright Yellow-2 Cells1 David A. Sorrell2, Margit Menges, J.M. Beyond Cell Cycle Cyclin dependent kinases (CDKs) and their associated cyclin partners have long been recognized as complexes that play an integral role in the progression The cyclin-dependent kinase 1 (Cdk1), formerly called Cdc2 (or p34 Cdc2), interacts with cyclin B1 to form an active heterodimer. Cyclin-dependent kinases (CDKs) are a family of sugar kinases first discovered for their role in regulating the cell cycle. I II TABLE 1 - CDKS AND THEIR ACTIVATING CYCLINS Putative CDK Species PSTAIRE epItope Family Associated cyclin Cell cycle stage Ref. A cyclin-dependent kinase functions to activate/inactivate proteins via phosphorylation and its activity depends the binding of a protein called cyclin How do Cdks control the cell cycle Cdks are responsible for activating proteins that Cyclin-dependent kinases (Cdks) are serine/threonine kinases and their catalytic activities are modulated by interactions with cyclins and Cdk inhibitors (CKIs). Cyclin-dependent kinase (CDK) 4/6 inhibitors are novel agents that have shown promising results in the treatment of breast cancer. Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate subunit - a cyclin - that provides domains essential for enzymatic activity. CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues. CDK4 and CDK6 are proteins that are part of a cell cycle regulatory pathway that also includes p16, cyclin D, This video shows how cyclin partners help in the progression of cell The role of the major CDKs (cyclin-dependent kinases) is shown relative to the four phases of the cell cycle. Cyclin-dependent kinases is a group of serine/threonine kinases. Cell cycle / cyclin / cyclin dependent kinases CDK / S cyclin / M cyclin - Duration: 0:52. Cyclin-Dependent Kinases. CYCLINS AND CELL CYCLE CHECKPOINTS ... of cyclins that associate with and activate cyclin-dependent kinases. Fig. It is activated by binding to cyclin and participates in the regulation of cell cycle. cyclin cdk cell cycle - The third lecture on cell cycle regulation explains the role of cyclin and cyclin dependent kinase proteins in cell cycle control. Start studying Cell Biology, Final Exam - Regulation of the ... MPF is a cyclin-dependent kinase ... which is required for cdc2 kinase activity later in the cell cycle. require cyclin subunits for activity. CYCLIN DEPENDENT KINASES AND CELL CYCLE CONTROL Nobel Lecture, December 9, 2001 by PAUL M. NURSE Cancer Research UK, PO Box 123, 61 Lincolns Inn Fields, London WC2A Each transition from one phase to another during the cell cycle, including entry into the cell cycle from G0 or nondividing cells, requires the formation and activation of a CDK CDKs play important roles in the control of cell division and modulate transcription in response to several extra- and intracellular cues. members are small proteins (~3440 kDa) composed of little more than the catalytic core. CDKs are a family of multifunctional enzymes that can modify various protein substrates involved in cell cycle progression. Cyclin-dependent kinases (CDKs) are a family of protein kinases first discovered for their role in regulating the cell cycle. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. 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